Detecting translational regulation by change point analysis of ribosome profiling
نویسنده
چکیده
Zupanic A, Meplan C, Grellscheid SN, Mathers JC, Kirkwood TBL, Hesketh JE, Shanley DP Centre for Integrated Systems Biology of Ageing & Nutrition, Institute for Ageing and Health, Newcastle University, Newcastle-upon-Tyne, NE4 5PL, UK Institute for Cell and Molecular Biosciences and Human Nutrition Research Centre, Newcastle University, Newcastle-upon-Tyne, NE2 4HH, UK School of Biological and Biomedical Sciences, Durham University, Durham DH1 3LE, UK
منابع مشابه
Detecting translational regulation by change point analysis of ribosome profiling data sets.
Ribo-Seq maps the location of translating ribosomes on mature mRNA transcripts. While during normal translation, ribosome density is constant along the length of the mRNA coding region, this can be altered in response to translational regulatory events. In the present study, we developed a method to detect translational regulation of individual mRNAs from their ribosome profiles, utilizing chan...
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تاریخ انتشار 2014